Guthix has been featured in many of Tehnoobshow's videos, such as Guthixscape, How Runescape Began, and Runescape Gods Exposed. He is one of the three gods of Runescape, along with Zamorak and Saradomin. He is famous for slamming his head into a wall and yelling, "Guthiiiixxxxxx!!!!!"

Guthix was also the main reason why the three gods had to move to the farm south of Falador in Runescape Gods Exposed, after destroying half of Falador.